- Behavioral Health Response: (314) 469-6644 and 1-800-811-4760
- Crisis Hotline: 1-800-833-3915
- Crisis Text Line: Text HOME to 741741
- Crisis Pregnancy Hotline: 1-800-672-2296
- Domestic Violence Hotline: 1-800-799-SAFE (7233)
- Drug Abuse National Helpline: 1-800-622-4357
- First Call for Help Hotline (English and Spanish): 1-800-492-0618
- Get Help Now: 1-800-999-9999
- Grief Share: 1-800-395-6946
- LGBTQ Hotline: 1-866-488-7386
- Military Crisis Line: 1-800-273-8255, press 1 or live chat; 24/7 Confidential Peer Support (855) 838-8255
- National Council on Problem Gambling: 1-888 BETS OFF (238-7633)
- National Hopeline Hotline (English and Spanish): 1-800-784-2433
- National Sexual Assault Hotline: 1-800-656-HOPE (4673)
- Safe Connections Hotline: (314) 531-2003
- SAFE Self Injury Hotline: 1-800-366-8288
- St. Louis Queer + Support Helpline: Local: (314) 380-7774 Toll-Free: (844) 785-7774
- Suicide Prevention Hotline: 1-800-273-TALK (8255)
- The Trevor Lifeline – LGBTQ-IA: (866) 488-7386
- Veterans Suicide Prevention Lifeline: 1-800-273-8255 and press 1